Clay Cross is a former industrial and mining town. It is a civil parish in the North East Derbyshire district of Derbyshire, England, about six miles south of Chesterfield. It is directly on the A61, the former Roman road Ryknield Street. Surrounding settlements include North Wingfield, Tupton, Pilsley and Ashover.

Clay Cross è un paese di 8.573 abitanti della contea del Derbyshire, in Inghilterra.